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A new therapeutic agent for leukemia:clofarabine;

新型抗白血病药氯法拉滨

This article summarizes the process mechanism, pharmacokinetics,pharmacodynamics,clinical studies and safety profile of clofarabine.

氯法拉滨是第2代嘌呤核苷酸类似物,对患有难治性或复发性急性淋巴细胞白血病的1～21岁病人有显著疗效,是近10年来首个FDA批准的专门用于治疗儿童白血病的新药。

Benzoylated clofarabine was achieved by reacting 2-chloroadenine with 1-deoxy-1-.

氯法拉滨是一种核苷类似物，对多种实体瘤均有作用，对急性白血病的治疗尤为有效，是FDA首个专用于治疗儿童白血病的药物。